Table 4.
FokI and BsmI polymorphisms and MS risk
| Genotype | MS n(%) | Control n(%) | P-value | OR | 95% CI |
|---|---|---|---|---|---|
| BsmIa | |||||
| BB(CC) | 347(89.0) | 328(82.0) | 1 | ||
| Bb(CT) | 42(10.7) | 69(17.3) | 0.009 | 0.575 | 0.381-0.869 |
| bb(TT) | 1(0.3) | 3(0.7) | 0.318 | 0.315 | 0.033-3.044 |
| Bb + bb | 43 | 72 | 1 | ||
| BB | 347 | 328 | 0.006 | 1.771 | 1.179-2.661 |
| B | 736(94.4) | 725(90.6) | 1 | ||
| b | 44(5.6) | 75(9.4) | 0.005 | 0.578 | 0.393-0.850 |
| FokIb | |||||
| FF(AA) | 75(19.2) | 80(20.0) | 1 | ||
| Ff(AG) | 184(47.1) | 207(58.9) | 0.779 | 0.948 | 0.653-1.376 |
| ff(GG) | 132(33.7) | 112(28.1) | 0.266 | 1.257 | 0.840-1.882 |
| Ff + ff | 316 | 319 | 1 | ||
| FF | 75 | 80 | 0.759 | 0.946 | 0.666-1.345 |
| F | 334(42.7) | 367(46.0) | 1 | ||
| f | 448(57.3) | 431(54.0) | 0.190 | 1.142 | 0.936-1.393 |
| BBFFc | 69 | 68 | 1 | ||
| BBFf | 164 | 174 | 0.761 | 0.929 | 0.624-1.382 |
| BBff | 114 | 85 | 0.211 | 1.322 | 0.854-2.046 |
| BbFF | 5 | 11 | 0.156 | 0.448 | 0.148-1.358 |
| BbFf | 19 | 32 | 0.111 | 0.585 | 0.303-1.131 |
| Bbff | 18 | 26 | 0.276 | 0.682 | 0.343-1.358 |
| bbFF | 0 | 1 | 1.000 | 0.000 | 0.000 |
| bbFf | 1 | 1 | 0.992 | 0.986 | 0.060-16.077 |
| Bbff | 0 | 1 | 1.000 | 0.000 | 0.000 |
a Ptrend = 0.02; b Ptrend = 0.216; c Ptrend = 0.187;BB/FF normally show dominant homozygous genotype; Bb/Ff show heterozygous genotype; bb/ff show recessive homozygous genotype.