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. 2014 Nov 12;33(1):92. doi: 10.1186/s13046-014-0092-7

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© Amini et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Combination treatment of MKN45, KATO-III, HT29-5F12, HT29-5M21 and LS174T cells with bromelain and NAC. Cells were treated for 72 hours with three concentrations of each agent on their own and in combination. In general, growth-inhibitory effects of combination therapy were significantly more potent than those induced by single agent treatment. Significant changes (p <0.05) are marked by bold (*) and non-bold (*) asterisks when single agent bromelain and NAC are considered as control, respectively.