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. 2014 Sep 5;31(12):3250–3265. doi: 10.1093/molbev/msu258

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© The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 3. — The α9 nAChR subunit defines the extent of calcium permeability of α9α10 receptors. (A) Percentage response to 100 μM ACh after 3-h incubation with the fast calcium chelator BAPTA-AM for heteromeric, homomeric, and hybrid nAChRs. The percentage of the initial response remaining after BAPTA incubation was determined for each oocyte individually and then averaged for each receptor. Values are mean ± SEM. (B) Relative calcium permeability (pCa/pNa) as determined from fitting E_rev data, as a function of extracellular calcium concentration, to the GHK equation extended to include divalent cations. Values are mean ± SEM. Note that whenever a rat α9 subunit is present calcium permeability is high and whenever a chicken α9 subunit is present the calcium permeability is low.