Fig. 3.

Depletion of Lbh results in cell-autonomous defects in NCC migration. (a–d) Dorsal views of uninjected (a) or lbh morphant (b–d) NCC reporter zebrafish [Tg(-7.2sox10:EFGP)] at 24 hpf. Arrowheads indicate accumulation of NCCs above the eye in morphants relative to controls. Lateral views of st.24 Xenopus with control (e) or morphant (f–g) NCC grafts. (h) Schematic of Xenopus NCC grafting experiment. Eye (e) is outlined with white dotted line. A, anterior; An, animal pole; br, branchial streams; cg, cement gland; D, dorsal; h, hyoid stream; m, mandibular stream; P, posterior; V, ventral; Veg, vegetal pole. Scale bars = 200 µm.