FIG. 8.

PTEN deficiency correlates with elevated NRF2 and HO-1 protein levels in human endometrioid tumors. (A) Immunohistochemistry performed in 4-μm-thick sections of human endometrial tumor. (B) Venn diagram showing evaluation and quantification of PTEN, NRF2, and HO-1 expression in tissue microarrays from 66 tumors of a cohort of patients with endometrioid cancer. (C) Contingency analysis of NRF2 and HO-1 expression in the 66 tumors using Pearson chi-square test followed by Fisher exact test in 66 patients. Pearson chi-square analysis indicates a statistical difference between observed distribution of NRF2 and HO-1 with a Fisher's p-value of 0.0004. (D) Analysis of PTEN expression in the 49 tumors that were positive for NRF2 and HO-1 determined in (C). Preacher's chi-square analysis indicates a statistical difference between observed distribution of NRF2 and HO-1 in the PTEN-negative tumors and the expected fair distribution with a Yate's, p-value of 9.4e-7. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars