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. 2014 Dec 1;16(6):439–446. doi: 10.1089/cell.2014.0054

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Copyright 2014, Mary Ann Liebert, Inc.

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FIG. 2. — Action potential firing patterns and tetrodotoxin-sensitive Na⁺ currents. (A) We identified four subpopulations of hiN cells characterized by different AP firing patterns: Nonfiring (30%), non-overshooting (33%), and overshooting (30%) single-spike firing, and repetitive firing (7%) hiN cells. (B) Expanded view of AP traces of the two hiN subpopulations with overshooting APs reveals strong variability in AP broadness due to heterogeneous repolarization times. (C) (Left) Example traces of sodium currents in response to voltage-step applications from −20 to +40 mV. (Right) Plot of the relationship between holding potential and the amplitude of resulting Na⁺ currents in 4 hiN cells. (D) Application of the Na_v-blocker TTX (1 μM) abolished AP firing, confirming the involvement of sodium currents in the observed APs.