Table 1.

Summary table of the effects during embryonic and adult hippocampal neurogenesis of the main pathways and transcription factors discussed in the text.

Gene/pathway	Effect during development	Effect in adult neurogenesis	Similar or different?
Wnt	Promotes proliferation and neuronal differentiation of neural precursors	Promotes activation of quiescent stem cells and enhances neuronal differentiation	Similar
BMPR-Ia	Promotes the proliferation of neural precursors	Maintains stem cells in a quiescent state	Different
Notch	Maintains the NSC pool by preventing premature differentiation	Maintains the NSC pool by preventing exit from quiescence	Similar
Neurog2	Determines the glutamatergic differentiation of NSCs	Expressed in glutamatergic neuronal precursors but function not directly tested	Similar?
Tbr2	Essential for the proliferation and differentiation of IPCs	Essential for the proliferation and differentiation of IPCs	Similar
Prox1	Promotes differentiation and determines granule cell identity	Expressed by granule neuron precursor cells, promotes differentiation	Similar
NFIX	Required for correct positioning of NSCs in the postnatal DG	Not analyzed (only straight knockout analyzed at P20)	?
Tlx	Does not have an important role in development of the DG	Essential for the proliferation of adult NSCs (although only straight knockout tested)	Different
CcnD2	Does not have an important role in development of the DG	Essential for the proliferation of adult NSCs (although only straight knockout tested)	Different
Ascl1	Does not have an important role in development of the DG	Essential for the proliferation of adult NSCs	Different