Figure 1.

Expression of CREB in hippocampus, nucleus accumbens and amygdala. (A) Hippocampal expression of CREB in (tamoxifen-treated) control animals with regular CREB expression and (B) in Creb^CamKCreERT2 mutant mice after induced ablation with tamoxifen in the adulthood with a definite loss of CREB expression in the pyramidal cell layer but not in putative GABAergic interneurons sparsely distributed in all hippocampal layers. (C) Expression of CREB in the nucleus accumbens (NAC) important for rewarding mechanisms in (tamoxifen-treated) control animals with regular CREB expression and (D) in Creb^CamKCreERT2 mutant mice after induced ablation with tamoxifen in the adulthood. (E) Expression of CREB in the basolateral amygdala (BLA) important for fear-related memory in control and (F) in Creb^CamKCreERT2 mutant mice after induced ablation with tamoxifen in the adulthood. N = 12 per genotype.