Figure 2.

Locomotion and Novel object exploration in the openfield. (A) Distance moved and (B) velocity is unaltered in Creb^CamKCreERT2 mutant mice compared to controls in the openfield without object (first 10 min) and after introduction of the novel object. (C) Center time and (D) mean distance to walls is reduced in Creb^CamKCreERT2 mutant mice, reflecting anxiety-like behavior. (E) Latency to approach the novel object is enhanced (p = 0.059) and (F) the number of approaches is decreased in Creb^CamKCreERT2 mutant mice compared to controls. Black bars: controls, white bars: Creb^CamKCreERT2 mutant mice, * p < 0.05, N = 24 per genotype.