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. 2014 Nov 27;8:407. doi: 10.3389/fnbeh.2014.00407

Figure 4.

Figure 4

Learning and Memory performance in Morris water maze and contextual fear conditioning. (A) Mutant mice with a loss of Creb in the adulthood do not show disturbed learning during acquisition in the Morris water maze as represented by the distance moved to reach the platform (repeated measurement ANOVA factor time: F(11,132) = 18.975, p < 0.001). All data points represent the mean (±SEM), N = 8 controls and N = 7 mutants. (B) Induced loss of Creb in the adulthood does not affect spatial reference memory in the Morris water maze as represented by the time spent in the target zone vs. the means of the 3 other quadrants during the probe trial (two-way ANOVA factor place: F(1,13) = 19.122, p < 0.001, factor genotype: F(1,13) = 1.752, p = 0.208). All data points represent the mean (+SEM), N = 8 controls and N = 7 mutants. (C) Induced loss of Creb in the adulthood does not affect hippocampus-dependent associative learning in the fear conditioning paradigm. All data points represent the mean (+SEM) percent time spent freezing during context replacement 24 h after training. N = 14 controls, N = 10 mutants.