Figure 5.

Analysis of CREM, ATF-1 and BDNF- mRNA level in hippocampus and frontal cortex. (A) Mutant mice with a loss of Creb at adulthood exhibit significant higher mRNA levels of CREM in the hippocampus and frontal cortex. (B) Induced loss of Creb did not affect ATF-1 mRNA level in hippocampus and frontal cortex. (C) Mutant mice express significantly less BDNF mRNA in the frontal cortex but its levels remain unchanged in the hippocampus. All data points represent mean (+SEM), stated as fold change of the control level. Black bars: controls, white bars: Creb^CamKCreERT2 mutant mice, ** p < 0.01, *** p < 0.001, N = 12 per genotype.