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. 2014 Oct 29;42(21):13096–13109. doi: 10.1093/nar/gku1030

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — UVC and Cr(VI) induce replication stress at telomeres. (A) Confocal images of eGFP-ATR U2OS cells exposed to UVC and allowed to recover for 6 h or exposed to Cr(VI) for 48 h. Cells were analyzed via IF-FISH of ATR (green) and telomere (red) co-localization (yellow). Average ATR foci and co-localized ATR and telomere foci per cell after indicated UVC dose (B) or Cr(VI) concentration (C). The data represent mean ± SE from two experiments and approximately 50 interphase cells. Significant difference from the mock is indicated with * above the bar, and significant difference between exposures is indicated with a * above the line; black lines refer to ATR foci comparisons, red lines refer to ATR+ telomere foci (P < 0.05). Bars, 10 μM.