Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 29;42(21):13096–13109. doi: 10.1093/nar/gku1030

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — UVC and Cr(VI) induce a DDR at telomeres. SV40 immortalized XP30RO-derived cells expressing polη (Wt) or vector alone (XPV) following irradiation with 5 J/m² UVC or 3 μM Cr(VI) for 48 h. Cells were analyzed via IF-FISH for 53BP1 (green), γH2AX (magenta) and telomere (red) co-localization (white) at 0- or 6-h recovery. (A) Confocal images of untreated Wt cells, and Wt and XPV cells exposed to UVC or Cr(VI) and allowed to recover for 6 h. Average DDR foci and telomere foci per cell after 0 or 6 h recovery from UVC (B) or Cr(VI) (C). Data represent averages from two independent experiments and a minimum of 50 cells. Bars with a symbol of * indicates a significant difference compared to mock exposure and between the various recovery time points (P < 0.05). Bars, 10 μM. Untreated, UT.