Table 2. Transcriptional targets of p53 were enriched among genes whose expression levels in cancers were correlated with the mutational loss of function of TP53.
| Cancer type | Total numbers of GEXP∼ΔTP53 | Number of GEXP∼ΔTP53 correlations which are possible p53 transcriptional targets | Enrichment in all GEXP∼ΔTP53's (hypergeom. P) | Number of negative correlations (GEXP lower | ΔTP53) | Number of positive correlations (GEXP higher | ΔTP53) |
|---|---|---|---|---|---|
| [all19] | 15 648 | 362 | 2.42 × 10-14 | 147 | 232 |
| brca | 7449 | 195 | 2.44 × 10-08 | 93 | 103 |
| lgg | 3059 | 70 | 0.044 | 41 | 29 |
| luad | 2193 | 67 | 3.96 × 10-05 | 32 | 36 |
| ucec | 2058 | 57 | 0.0017 | 29 | 28 |
| gbm | 365 | 27 | 5.04 × 10-10 | 20 | 7 |
| hnsc | 519 | 27 | 9.01 × 10-07 | 20 | 8 |
| coad/ read | 224 | 24 | 1.41 × 10-12 | 22 | 2 |
| skcm | 63 | 19 | 0 | 19 | 0 |
| stad | 270 | 10 | 0.015 | 9 | 1 |
| blca | 12 | 6 | 6.35 × 10-10 | 6 | 0 |
Shown are statistics for the identification of probable p53 transcriptional targets whose expression levels were correlated with TP53 mutation status (ΔTP53) in several distinct cancer types. Four hundred and eighteen genes were estimated to be probable p53 transcriptional targets based on multiple ChIP experiments, the presence of accessible p53 transcription factor DNA-binding site sequences in gene upstream regions, and previously curated evidence (Supplementary Table S4).