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. 2014 Nov 5;42(21):13161–13173. doi: 10.1093/nar/gku1089

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — The presence of PARP1 affects interaction between mitochondrial DNA repair enzymes. (A) Binary interactions between three mitochondrial-specific DNA repair enzymes (EXOG, Polγcat and Polγacc (catalytic and accessory subunit of DNA Polγ) and other DNA repair enzymes were analyzed by PLA in control and PARP1-depleted A549 cells under baseline and oxidative stress conditions. (B) Representative autoradiogram of the total DNA repair activity of control and PARP1-depleted A549 cells of mitochondrial extracts isolated from resting and oxidatively stressed cells. Incorporation of ³²P-dATP into THF containing 52-nt long oligo duplex is shown. The graph represents quantification of the total mitochondrial DNA repair expressed as means±SD calculated based on three independent experiments (*P < 0.05).