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. 2014 Oct 7;42(21):e161. doi: 10.1093/nar/gku864

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Surrogate variable analysis (sva). The general sva framework for identifying unknown artifacts in genomic data has three steps (4,5).