Table 3. Percent of total insoluble protein composed of amyloidogenic proteins in renal cortex and medulla.
% Total protein | |||||||||||||
Apolipoproteins | |||||||||||||
Animal ID | Kidney region | AA | Ig-λ | Fib-α | TTR | A-I | A-II | A-IV | β2M | Cys | Gel | Lys | |
5 | cortex | 42.32 | 2.50 | 0.57 | 0.05 | 0.22 | 0* | 0.13 | 0 | 0 | 0 | 0 | |
medulla | 39.42 | 2.28 | 0.21 | 0 | 0.12 | 0 | 0.48 | 0 | 0 | 0 | 0.33 | ||
7 | cortex | 0 | 0.90 | 0.21 | 0 | 0.08 | 0 | 0 | 0.02 | 0 | 0 | 0 | |
medulla | 24.17 | 2.99 | 0.16 | 0.17 | 1.06 | 0 | 0.95 | 0.08 | 0 | 0.03 | 0 | ||
Amyloid | 6 | cortex | 26.31 | 4.00 | 0.39 | 0.08 | 1.76 | 0 | 0.01 | 0 | 0 | 0 | 0.04 |
positive | medulla | 12.59 | 2.60 | 0.55 | 0 | 2.59 | 0 | 0 | 0 | 0 | 0 | 0 | |
8 | cortex | 0 | 5.55 | 0.10 | 0.02 | 0.29 | 0 | 0 | 0 | 0 | 0 | 0.10 | |
medulla | 48.31 | 1.91 | 0.08 | 0.03 | 0.42 | 0 | 0.33 | 0 | 0 | 0.04 | 0.10 | ||
4 | cortex | 5.57 | 1.96 | 0.05 | 0 | 0.21 | 0 | 0 | 0 | 0 | 0 | 0.04 | |
9 | medulla | 19.74 | 3.12 | 0.14 | 0.57 | 2.08 | 0.10 | 0.71 | 0 | 0.14 | 0.07 | 0 | |
10 | medulla | 33.21 | 2.98 | 0.95 | 0.08 | 1.73 | 0 | 0.51 | 0 | 0.26 | 0.02 | 0 | |
1 | cortex | 0 | 4.10 | 0.03 | 0 | 0.52 | 0 | 0 | 0 | 0 | 0 | 0 | |
medulla | 0 | 4.41 | 0.10 | 0 | 0.68 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Amyloid | 2 | cortex | 0 | 1.47 | 0 | 0 | 0.28 | 0 | 0 | 0 | 0 | 0 | 0.21 |
negative | medulla | 0 | 3.11 | 0 | 0 | 0.40 | 0 | 0 | 0.02 | 0 | 0 | 0 | |
3 | cortex | 0 | 3.37 | 0.03 | 0.42 | 0.71 | 0 | 0 | 0.01 | 0 | 0 | 0.09 |
Ig = immunoglobulin; Fib = fibrinogen; TTR = transthyretin; β2M = β2 microglobulin; Cyr = cystatin C; Gel = gelsolin; Lys = lysozyme. * 0 = normalized spectral count of <0.01%.