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. Author manuscript; available in PMC: 2014 Nov 27.
Published in final edited form as: Contrast Media Mol Imaging. 2012 Mar-Apr;7(2):160–166. doi: 10.1002/cmmi.475

Table 2.

IC50 values (with the 95% confidence interval in parenthesis) of [Lys40(natIn-DTPA)]exendin-3, [Lys40(natIn-DTPA)]exendin-4 and [Lys40(natIn-DTPA)]exendin(9-39) determined in a competition binding assay in INS-1 cells. The dissociation constant (Kd) and the Bmax (with the 95% confidence interval in parenthesis) of [Lys40(111In-DTPA)]exendin-3, [Lys40(111In-DTPA)]exendin-4 and [Lys40(111In-DTPA)]exendin(9-39) determined by a binding saturation experiment in INS-1 cells.

Compound IC50 (nM) Kd (nM) Bmax (receptors/cell)
[Lys40(DTPA)]exendin-3 13.5 (9.9 – 18.5) 8.7 (7.6 – 10.1) 26,000 (24 × 103 – 29 × 103)
[Lys40(DTPA)]exendin-4 13.4 (10.5 – 17.0) 17.6 (14.2 – 23.3) 41,000 (35 × 103 – 50 × 103)
[Lys40(DTPA)]exendin(9-39) 14.4 (4.8 – 43.2) 15.1 (6.9 – 80.7) 37,000 (13 × 103 – 60 × 103)