Table 2. Brain Regions Demonstrating Significant Between-Condition (Ketamine Greater Than Placebo) Differences in Functional Connectivity and Association with Symptom Change Scores (Ketamine–Placebo).
| Main effect (Figure 2) | Anatomical region | Hemisphere | MNI peak coordinates x, y, z | Z (df=1, 68) | Voxels |
|---|---|---|---|---|---|
| (a) DC | Thalamus | Right | 6, −18, 2 | 3.64 | 552 |
| Thalamus | Left | −14, −18, 6 | 3.38 | ||
| Midbrain | Left | −18, −16, −12 | 3.38 | ||
| Midbrain | Right | 12, −16, −10 | 2.88 | ||
| (b) VS | Superior ventromedial prefrontal cortex | Left | −8, 64, 2 | 3.62 | |
| Frontopolar cortex | Left | −6, 68, −6 | 3.22 | 582 | |
| Inferior ventromedial prefrontal cortex | Left | −16, 62, −2 | 3.06 |
| Behavioral association (Figure 3) | Anatomical region | Hemisphere | MNI peak coordinates x, y, z | Z (df=1, 31) | Voxels |
|---|---|---|---|---|---|
| (a) DC (BPRS) | Midbrain | Right | 10, −14, −10 | 5.08 | 84 |
| (b) DC (RSPS) | Midbrain | Right | 8, −12, −10 | 2.65 | 12 |
| (c) DC (CADSS) | Ventrolateral thalamus and subthalamic nucleus | Left | −18, −12, 0 | 2.86 | 18 |
| (c) DC (RSPS) | Ventrolateral thalamus and subthalamic nucleus | Left | −12, −14, 2 | 3.11 | 31 |
| (d) VS (BPRS) | Superior ventromedial prefrontal cortex | Left | 0, 58, 8 | 3.58 | 31 |
| (e) VS (CADSS) | Inferior ventromedial prefrontal cortex | Left | −6, 60, −10 | 4.04 | 47 |
Abbreviation: DC, dorsal caudate; VS, ventral striatum.
Results are thresholded at P<0.05 (FWE) cluster corrected.