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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Biochim Biophys Acta. 2014 May 27;1849(2):196–200. doi: 10.1016/j.bbagrm.2014.05.021

Fig. 1. BA signaling activates FXR to promote liver regeneration.

Fig. 1

Liver resection or injury increases BA influx, which activates FXR in the liver and intestine. After activation, liver-FXR suppresses Cyp7a1 to reduce BA production and activates Foxm1b to stimulate liver regeneration. Intestine-FXR is also activated to induce FGF15 expression, which circulates with BAs back to liver through enterohepatic circulation. FGF15 binds to its receptor (FGFR) and initiate a signaling pathway to suppress Cyp7a1 expression. At the same time, FGF15 also promotes liver regeneration through unknown mechanism.