Alterations in mucosal gene expression were determined by microarray analysis of lung, colon, and jejunum samples from chronically SIV infected animals (n=5) versus healthy uninfected controls (n=5). Venn diagrams reflect the different numbers (size) of up and down regulated genes in the lung, colon, and jejunum, as well as the overlaps in regulation between compartments. The predominant biological pathways and processes statistically (p-value < 0.05) implicated by the genes modulated at each mucosal site during SIV infection are shown in the bottom panel.