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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 7;192(7):3308–3318. doi: 10.4049/jimmunol.1302415

Figure 8. Comparison of lung and GI tract CD8+ T-cell responses in SIV infected macaques.

Figure 8

(A) Flow cytometric analysis of changes in CD8+ T-cell populations in the lung, colon, and jejunum expressing perforin and/or the degranulation marker, CD107a in response to SIV infection. A representative animal shown, (n=5). (B) In vitro production of IFNγ, IL-2, and TNFα in response to SIV gag stimulation was evaluated in CD8+ T-cells isolated from the lung, colon, and jejunum at 10 weeks post SIV infection (n=5). (C) Changes in the expression of granzymes K and H in the lung, colon, and jejunum during chronic stage SIV infection were determined by microarray analysis. *p-value<0.05