Figure 5.

The effect of rate of mutation to resistance (θ) on direct and indirect effects. A: the drug does not reduce disease transmission (γ = 0) and resistance comes with cost c = 0.1; B: the drug does reduce disease transmission ($\gamma =0.5$) and resistance comes with cost c = 0.1; C: the drug reduces transmission ($\gamma =0.5$) but resistance is cost-free (c = 0). Treatment start time τ is set to 60 days; the efficacy of the drug to reduce infection duration is ϵ = 0; stockpile size is $k=0.1N$; the remaining parameters except θ are as given in Table 1