Figure 6.

Effects under zero effect of treatment on transmission rate (γ = 0) and recovery time (ϵ = 0). A, B: direct and indirect effects and weighted sum as a function of the starting time τ with no cost c of resistance (panel A) and a small cost, c = 0.1 (panel B). Here, the fraction treated is f = 0.5. C, D: direct effects of drugs as a function of both treatment start time τ and proportion of cases treated f, with limited stockpile ($k/N=0.1$, panel C) and unlimited stockpile ($k/N=1$, panel D) of drugs. Here, the cost of resistance is set to zero. The other parameters are as given in Table 1: recovery rate $\nu =0.17$, mutation rate $\theta =0.01$, population size $N={10}^6$, basic reproductive ratio for susceptible untreated cases $R_{0,SU}=1.8$; β is computed from $R_{0,SU}$ and ν. The effects are given in units of thousands of cases