TABLE 3.

PISA-based calculated energy of the interface of the four REP domains with their intra-APC hexamer surrounding

REP domain	Core subcomponent	Total ΔGa
		kcal/mol
REP1	ApcC	−0.77 ± 0.33
	ApcA	0.53 ± 0.56
	ApcB	−0.96 ± 0.07
REP2	ApcC	3.03 ± 0.42
	ApcA	3.83 ± 0.48
	ApcB	−1.72 ± 0.36
REP3	ApcC	−3.43 ± 0.76
	ApcA	−0.98 ± 0.49
	ApcB	−0.06 ± 0.00
REP4	ApcC	−3.00 ± 0.34
	ApcA	−0.39 ± 0.54
	Chromophore: ApcB	−0.12 ± 0.21

^a The interaction energies of the minimized models were calculated using PISA. The ΔG values are the summary of all interactions within the specified components.