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. 2014 Oct 23;289(48):33231–33244. doi: 10.1074/jbc.M114.610022

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FIGURE 2. — ER-anchored CAD or OASF co-localizes with and constitutively activates Orai1 channels. A, time course of inward currents from HEK293 cells co-expressing fluorescently labeled TMG-CAD + Orai1 and TMG-OASF + Orai1, as well as STIM1 or Orai1 as control, and (B) the respective current-voltage relationship. Fluorescence images showing localization and overlay of (C) C-Orai1 + Y-TMG-OASF, (D) C-Orai1 + Y-TMG-CAD, and (E) C-Orai1 + Y-TMG-CC3₄₄₉. The bar in each fluorescence image corresponds to 5 μm.