FIGURE 3.

A seven-blade β-propeller model of WDR68 based on computational structural analysis. A, schematic illustration of five WD40 repeats (depicted as WD40-1 to WD40-5 with their starting and ending amino acid numbers) in the WDR68 amino acid sequence. B and C, a three-dimensional model of WDR68 showing a seven-blade β-propeller structure was obtained by analyzing its amino acid sequence with the Phyre² program. Colors used in the scheme (A) and the structure (B and C) are as follows: orange, aa 1–64 (N-terminal extension); yellow, aa 65–101 (WD40-1); red, aa 115–150 (WD40-2); green, aa 170–206 (WD40-3); cyan, aa 218–252 (WD40-4); blue, aa 262–296 (WD40-5); magenta, aa 297–342 (C-terminal extension). Ribbon models (B and C) and ball models (B′ and C′) are illustrated. Vertical views (B, B′, and B″) and side views (C, C′, and C″) are shown, and the arrows in B and in C indicate the direction from which the side and vertical view images are obtained, respectively. In the vertical view images (B), the amino acid sequence starts from the top of the image and runs clockwise to the C-terminal end. In B″ and C″, β-strands are shown in gray ribbons, and other regions are shown as colored wire strands.