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. 2014 Oct 15;289(48):33557–33567. doi: 10.1074/jbc.M114.607176

FIGURE 6.

FIGURE 6.

Comparison of human antibody structures containing insertions. Molecular surface representation of the crystal structures of Fabs of human antibodies with different specificities featuring insertions ranging from 4 to 9 amino acids. CDRH1 (yellow), CDRH2 (green), CDRH3 (blue), CDRL1 (yellow), CDRL2 (green), CDRL3 (pink), and insertions (red) are shown in the same orientations in a top view onto the combining site. A, APE1551, an anti-human βNGF antibody with a 9-residue insert in CDRH1 (PDB code 4NWU). B, bH1, a dual specific antibody to HER2 and VEGF, 4-residue insert in CDRL1 (PDB code 3BDY) (47). C, PGT127, an anti-gp120 antibody that recognizes conserved glycan residues, 6-residue insert in CDRH1, 4-residue deletion in CDRL1 (PDB code 3TWC) (15). D, C05, an anti-influenza A hemagglutinin antibody, 5-residue insert in CDRH1 (PDB code 4FP8) (17). E, VRC06, an anti-gp120 antibody, 7-residue insert in heavy chain FR3, 1-residue deletion in CDRL1 (PDB code 4JB9) (48). F, PGT135, an anti-gp120 antibody, 5-residue insert in CDRH1 (PDB code 4JM2) (49).