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. 2014 Oct 10;289(48):33655–33662. doi: 10.1074/jbc.M114.611236

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — SIN3A is necessary for induction of CYP1A1 mRNA by TCDD in the human hepatoma cell line Hep3B. Hep3B cells were transfected with three different siRNAs to human SIN3A and subsequently analyzed for the expression of SIN3A and CYP1A1 mRNAs after TCDD treatment. The negative control is the average of cells treated with a scrambled siRNA (SCR) or untreated with any siRNA (Mock). Data were normalized to the levels of GAPDH mRNA. **, p < 0.01; ***, p < 0.001 compared with Mock + SCR controls. Error bars, S.D.