Table 2.

Randomized-withdrawal period: mean (SD) CHIP-CE: PRF T-scores at baseline and endpoint (n = 153)

	Baseline		Endpoint
	LDX (68 ≤ n ≤ 73)	Placebo (71 ≤ n ≤ 73)	LDX (59 ≤ n ≤ 62)	Placebo (62 ≤ n ≤ 65)
Achievement	39.6 (10.58)	41.2 (11.11)	40.1 (11.70)	35.3 (11.63)
Academic Performance	40.7 (11.42)	41.1 (10.14)	40.6 (13.46)	34.4 (12.41)
Peer Relations	42.0 (10.77)	45.3 (12.13)	43.1 (11.56)	42.4 (12.84)
Risk Avoidance	45.8 (9.08)	46.8 (9.11)	47.5 (9.16)	41.3 (10.53)
Individual Risk Avoidance	50.3 (10.02)	51.0 (10.08)	52.7 (8.66)	47.7 (11.54)
Threats to Achievement	44.4 (9.08)	45.4 (9.04)	45.5 (10.13)	39.8 (10.08)
Resilience	42.0 (11.56)	42.6 (11.87)	43.3 (11.25)	40.2 (13.79)
Family Involvement	43.2 (12.46)	41.5 (12.46)	43.2 (10.74)	40.3 (14.73)
Physical Activity	47.7 (11.57)	49.1 (10.85)	48.2 (11.72)	49.4 (11.81)
Social Problem-Solving	43.0 (11.05)	44.6 (12.11)	45.1 (11.71)	40.9 (11.90)
Satisfaction	41.9 (11.40)	43.3 (13.19)	44.9 (11.88)	39.3 (14.83)
Satisfaction with Health	45.8 (10.90)	46.1 (13.13)	48.0 (11.89)	42.6 (13.88)
Satisfaction with Self	39.6 (12.51)	42.1 (11.28)	42.6 (10.67)	38.4 (12.95)
Comfort	51.0 (8.43)	51.1 (8.92)	51.1 (9.32)	48.5 (9.94)
Physical Comfort	55.9 (6.53)	53.2 (8.75)	54.3 (8.04)	53.6 (9.11)
Emotional Comfort	45.7 (10.37)	48.0 (10.38)	47.9 (9.76)	44.2 (11.15)
Restricted Activity	52.5 (8.11)	52.7 (6.91)	51.0 (10.48)	50.0 (9.50)

See Table 1 for definitions of baseline and endpoint. A T-score of 43 or below indicates poor HRQoL in a domain or subdomain; a T-score of 57 or above indicates excellent HRQoL [20]. See Supplementary Table A for corresponding medians and ranges. Numbers of observations (n) for each domain or subdomain were in the ranges indicated and varied depending on data validity. These data were not analysed statistically

CHIP-CE: PRF Child Health and Illness Profile-Child Edition: Parent Report Form, LDX lisdexamfetamine dimesylate, SD standard deviation