Fig. 2.

Computationally predicted structural conformations of the TMH5–6 region of wild-type AtCESA1, 3, 6, and the Atcesa1^F954L and Atcesa3^ixr1-2 (T942I) mutants. Models shown are representative of the “up” or “down” structural conformations. The “up” conformation indicates that the intervening region between TMH5 and 6 is extended away from the helices, whereas it forms a β-hairpin structure parallel to the axes of the helices in the “down” conformation. For all decoys, TMH5 is oriented on the left-hand side and TMH6 is on the right-hand side.