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. 2014 Nov 4;6(11):4165–4177. doi: 10.3390/v6114165

Figure 1.

Figure 1

Working model of KSHV PAN lncRNA action. (A) Decoy. Expression of PAN RNA sequesters LANA (left) and chromatin modifying complexes such as PRC2 (right) from the KSHV genome that reduces or prevents H3K27me3 mark deposition [1]. (B) Guide/Scaffold. PAN RNA aids in the targeting of regulatory factor complexes to specific loci of viral or cellular genes, which regulate gene expression to suit viral needs requiring (a) activation (i.e., ORF50 locus during reactivation) (b) repression (i.e., cellular response to viral infection or reactivation [23,43,44]. Mechanisms of PAN RNA targeting to specific loci is currently unknown. Not shown is the potential for PAN RNA to act in cis as a lncRNA signal [1]. Large curved green arrows indicate complex eviction (upward arrow) or deposition (downward arrow) from a genomic locus. Histones are depicted as cylinders with histone tails emanating, (red tail, activation; blue tail, repression) K27 (demethylated histone H3K27) and K27me3 (histone H3K27 tri-methylated; repressive mark); K4 (histone H3K4, substrate for methylation, activating mark).