Skip to main content
. 2014 Nov 4;6(11):4165–4177. doi: 10.3390/v6114165

Table 1.

Mechanisms of lncRNA action.

Name of lncRNA Nature of lncRNA/Mode of Action Consequence of the Regulation Reference
ANRIL, HOTAIR, XIST, H19, KCNQ1OT1 Scaffold molecule/Histone modification Epigenetic gene silencing [6,9,10,11,12]
NEAT1 Scaffold molecule/Protein assembly Paraspeckles formation [13]
MALAT1 Modifier of alternative splicing/Relocation of splicing factor Modulation of alternative splicing [14]
BACE1AS Regulation of mRNA stability/Modification of mRNA stability Increased translation of BACE1 [15]
Pseudo-NOS Translational control/Displacement of ribosome Repressed translation of nNOS [16]
GAS5 Decoy for DNA binding/Inhibition of DNA binding Repressed GR mediated gene activation [17]