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. 2014 Nov 4;6(11):4212–4226. doi: 10.3390/v6114212

Figure 2.

Figure 2

PAN RNA both activates and represses gene expression depending on its interaction with chromatin modifying complexes. (A) The interaction of PAN RNA with LANA during reactivation is partly responsible for the LANA-episome dissociation allowing for the expression of lytic transcripts. In this model PAN RNA acts as a “sponge” to keep LANA from repressing viral gene expression; (B) The interaction of PAN RNA with UTX/JMJD3 targets H3K37 for demethylation and acts to increase gene expression. The interaction of PAN RNA with viral encoded processivity factor ORF59 may aid in the targeting UTX/JMJD3 to viral genes during lytic gene expression; (C) PAN RNA’s interaction with PRC2 targets H3K27 for methylation and acts to repress gene expression. The mechanism for specific targeting of PAN RNA is currently under investigation.