Table 2.
BioCycle Study population mean (standard deviation) biomarker levels by estimated glomerular filtration rate (eGFR) status (2005-2007)
| Reduced eGFR (<90 ml/min/1.73m2) | ||||
|---|---|---|---|---|
| Characteristic | Total n=257 | No n=173 | Yes n=84 | p value |
| Biomarkers | ||||
| Metals | ||||
| Blood cadmium (μg/l) | 0.36 (0.29) | 0.36 (0.32) | 0.35 (0.23) | 0.70 |
| Blood lead (μg/dl) | 1.03 (0.63) | 1.03 (0.54) | 1.02 (0.80) | 0.95 |
| Blood mercury (μg/l) | 1.50 (1.33) | 1.59 (1.41) | 1.28 (1.29) | 0.06 |
| Cycle 1 Day 2 | ||||
| Kidney Biomarkers | ||||
| Albumin (g/dl) | 4.03 (0.25) | 4.05 (0.25) | 3.98 (0.25) | 0.04 |
| BUN (mg/dl) | 9.66 (3.31) | 9.36 (3.24) | 10.26 (3.39) | 0.04 |
| Chloride (mmol/l) | 105.17 (2.50) | 105.1 (2.52) | 105.2 (2.48) | 0.78 |
| CO2 (mmol/l) | 24.38 (1.61) | 24.41 (1.56) | 24.31 (1.71) | 0.64 |
| Creatinine (mg/dl) | 0.76 (0.12) | 0.7 (0.09) | 0.87 (0.10) | <0.001 |
| Glucose (mg/dl) | 87.22 (6.60) | 87.47 (6.20) | 86.73 (7.35) | 0.39 |
| Potassium (mmol/l) | 4.04 (0.37) | 4.02 (3.7) | 4.08 (0.38) | 0.17 |
| Protein (g/dl) | 6.67 (0.36) | 6.69 (0.35) | 6.62 (0.36) | 0.13 |
| Uric acid (mg/dl) | 4.15 (0.77) | 4.06 (0.75) | 4.34 (0.77) | 0.005 |
| Liver Biomarkers | ||||
| ALT (U/L) | 17.22 (11.37) | 16.14 (6.38) | 19.43 (17.53) | 0.10 |
| ALP (U/L) | 51.51 (14.17) | 50.48 (14.64) | 53.64 (13.00) | 0.09 |
| AST (U/L) | 19.59 (7.67) | 19.03 (5.93) | 20.76 (10.33) | 0.16 |
| Bilirubin (mg/dl) | 0.77 (0.29) | 0.76 (0.29) | 0.79 (0.29) | 0.37 |
| Reproductive hormones | ||||
| Estrogen (day 2) (pg/ml) | 38.01 (28.18) | 35.62 (18.34) | 42.91 (41.42) | 0.13 |
| FSH (day 2) (mIU/ml) | 6.89 (3.45) | 6.90 (3.54) | 6.85 (0.36) | 0.90 |
| Progesterone (day 22) (ng/ml) |
8.46 (5.30) | 8.68 (5.52) | 8.09 (4.92) | 0.41 |
| LH (day 14) (ng/ml) | 13.74 (14.27) | 12.80 (12.70) | 15.68 (16.97) | 0.13 |