Table 2.
Vascular parameters in non-arthritic and arthritic mice
| VOI 1 | VOI 2 | VOI 3 | VOI 4 | ||
|---|---|---|---|---|---|
| TV [mm 3 ] | WT | 10.6 ± 5.2 | 34.6 ± 4.9 | 59.6 ± 4.6 | 69.0 ± 7.0 |
| hTNFtg | 11.5 ± 3.1 | 40.0 ± 11.3 | 66.0 ± 13.4 | 78.4 ± 14.4 | |
| VV/TV [%] | WT | 5.9 ± 3.1 | 2.0 ± 0.62 | 1.1 ± 0.51 | 1.4 ± 0.52 |
| hTNFtg | 3.7 ± 1.8 | 3.2 ± 0.7 | 1.8 ± 0.4 | 2.4 ± 0.3 | |
| VS [mm 2 ] | WT | 6.2 ± 3.7 | 8.4 ± 3.02 | 9.4 ± 3.81 | 12.5 ± 5.02 |
| hTNFtg | 6.0 ± 1.9 | 18.7 ± 7.9 | 16.0 ± 5.6 | 22.3 ± 5.4 | |
| V.Th 3D [μm] | WT | 81.4 ± 19.51 | 71 ± 14.6 | 56.2 ± 10.2 | 57.4 ± 7.1 |
| hTNFtg | 59.0 ± 13.9 | 61 ± 9.1 | 65.0 ± 21.5 | 64.0 ± 6.5 | |
| V.N 2D [1/mm] | WT | 1.4 ± 0.3 | 0.9 ± 0.23 | 0.8 ± 0.12 | 0.8 ± 0.12 |
| hTNFtg | 1.6 ± 0.2 | 1.5 ± 0.2 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| V.Sp 2D [mm] | WT | 0.6 ± 0.2 | 0.9 ± 0.23 | 1.1 ± 0.22 | 1.1 ± 0.21 |
| hTNFtg | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | |
TV: total volume; VV: vessel volume; VS vessel surface; V.Th3D: vessel thickness; V.N2D: vessel number; V.Sp2D: vessel spacing; WT: wild type mice; hTNFtg: human tumor necrosis factors transgenic mice.
10.01 ≤ p < 0.05. 20.001 ≤ p <0.01; 3p < 0.001.