Table 2.

Effects of chronic systemic SR141716A or vehicle treatment in (mRen2)27 rats

Parameter	(mRen2)27 Vehicle	(mRen2)27 SR 10 mg/kg/day
Plasma Ang I (pg/mL)	353 ± 112	302 ± 52
Plasma Ang II (pg/mL)	71 ± 25	69 ± 11
Plasma Ang‐(1–7) (pg/mL)	45 ± 7	46 ± 7
Serum ACE (ng/mL)	26 ± 2	30 ± 4
Urine vasopressin (pg/mL)
Baseline	107 ± 12	104 ± 16
Day 21	100 ± 19	110 ± 31
Urine osmolality (mOsm/L)
Baseline	1471 ± 107	1528 ± 77
Day 21	1639 ± 110	1809 ± 69**

Values are mean ± SEM. SR refers to SR141716A.

**P < 0.01 versus Baseline; n = 7–8 all groups.