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. 2014 Aug 19;2(8):e12116. doi: 10.14814/phy2.12116

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — ELVs carry most of the small GTPases known to regulate the exocyst complex. Schematic diagram illustrating the interactions between the different exocyst subunits and the nine mammalian GTPases, known to regulate the exocyst complex that we found in human urinary ELVs. “Ortholog of yeast GTPase” refers to mammalian orthologs of yeast GTPases that interact with the exocyst. “Yeast ortholog and/or vertebrate GTPase”, refers to mammalian GTPases that interact with the exocyst (the yeast ortholog of Rab8 is Sec4, and both Rab8 and Sec4 have been shown to interact with the exocyst, so that is included here as well).