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. 2014 Aug 8;2(8):e12092. doi: 10.14814/phy2.12092

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Effect of ionotropic glutamate receptor blockade in the NTS on the hypercapnic ventilatory response in normoxic control (CON) versus chronically hypoxic (CSH) rats. Effects of acute hypercapnia (7% CO₂) and MK801 + DNQX on (A) total minute ventilation (i), (B) breathing frequency (fr), and (C) tidal volume (Vt) of CON and CSH rats before and after microinjection of drugs. Data are mean ± SEM from n =7 CON and 9 CSH rats. Asterisks (*) indicate significant (P < 0.05) difference between CON and CSH values. Daggers (†) indicate significant effect of drug relative to ACSF microinjection.