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. 2014 Aug 19;2(8):e12111. doi: 10.14814/phy2.12111

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Opioid sensitivity of inspiratory rhythms in “sandwich” slice pairs from a single brainstem. (A) Schematics of adjacent sandwich slices and suction electrode positions. In some experiments the suction electrode in the XII nucleus was repositioned to record the contralateral preBötC, that is, cl‐preBötC. (B) Electrodes were initially positioned to record the preBötC area and the XII nucleus in a sandwich slice pair. Since the caudal slice showed no XII activity, the electrode was moved. Synchronous oscillations were present in the preBötC bilaterally. Right traces show synchronous preBötC and XII nucleus activity in the rostral slice of the pair. (C) In different sandwich slice pair, with the anterior border 0.40 mm and the posterior border 0.35 mm caudal to VII_c, respectively, bath‐application of 1 μmol·L⁻¹ DAMGO reversibly abolished preBötC rhythm which partially recovered upon washout. (D) Scatter plot of burst rates in caudal (gray circles) and rostral (black circles) in superfusate (control), during bath‐application of DAMGO (1 μmol·L⁻¹) and washout.