Table 1.

In vitro susceptibilities of Candida isolates to a standard preparation of HDCL

Candidaspp.	Planktonic MIC (μg/ml)			Biofilm MIC (μg/ml)
	MIC range	MIC 50	MIC 90	MIC range	MIC 50	MIC 90
Candida albicans ( n = 15)	128 - 256	256	256	128 - 512	256	256
Nonalbicans Candida species (n = 77)	64 - 256	256	256	64 - 1024	256	256
Candida glabrata (n = 26)	64 - 256	256	256	64 - 512a	256a	512a
C. krusei (n = 17)	128 - 256	128	256	64 - 256	128	256
C. parapsilosis (n = 8)	64 - 256	64	256	128 - 1024b	128b	1024b
C. tropicalis (n = 10)	64 - 256	128	256	256 - 1024	256	512
C. orthopsilosis (n = 8)	128 - 256	256	256	128 - 256c	128c	256c
C. rugosa species complex (n = 5)	128 - 256	128	256	128 - 512	512	512
C. dubliniensis (n =1)	128	ND	ND	256	ND	ND
M. guelliermondii (n =1)	128	ND	ND	128	ND	ND
C. metapsilosis (n =1)	256	ND	ND	128	ND	ND
All isolates (n = 92)	64 - 256	256	256	64 - 1024	256	512

Footnote: Planktonic MIC: The lowest concentration of HDCL required to inhibit yeast growth after incubation at 37°C for 48 h.

Biofilm MIC: The lowest concentration of HDCL required to cause 50% reduction in biofilm metabolic activity after incubation at 37°C for 48 h.

MIC₅₀ and MIC₉₀ values were only calculated for those species with 5 or more isolates.

ND: Not determined.

^{a, b, c}: Five Candida glabrata and two each of C. parapsilosis and C. orthopsilosis isolates were excluded from the study due to poor biofilm formation (OD_490nm < 0.1).