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. 2014 Oct 15;9(1):365–370. doi: 10.3892/ol.2014.2621

Figure 1.

Figure 1

Expression of IE1–72, TLR2, TLR4, NF-κB and TNF-α in colorectal cancer tissues, adenoma and normal tissues. (A) The expression of IE1–72 in colorectal carcinomas was positive (magnification, ×100). The IE1–72 protein is visible as brown granules located in the nucleus. (B) IE1–72 expression from part A (enclosed by a black box) is shown at a higher magnification (x400). (C) The positive expression of IE1–72 was identified in adenoma, visualized as brown granules located in the cytoplasm (magnification, ×100). (D) The negative expression of IE1–72 in normal tissues (magnification, ×400). (E) The positive expression of TLR2 in colorectal carcinomas was indicated by brown particles located in the cytoplasm (magnification, ×100). (F) The negative expression of TLR2 in colorectal cancer (magnification, ×400). (G) The positive expression of TLR2 in adenoma (magnification, ×100). (H) The negative expression of TLR2 in normal tissues (magnification, ×100). (I) The positive expression of TLR4 in colorectal carcinomas (x100) was localized by brown particles in the cell membrane and cytoplasm. (J) TLR4 expression from part I (enclosed by a black box) is shown at a higher magnification (x400). (K) The positive expression of TLR4 in adenoma corresponds to the colored portions of cytoplasm and membrane (magnification, ×400). (L) The positive expression of TLR4 in normal tissues (magnification, ×100). (M) The positive expression of NF-κB in colorectal cancer tissues (magnification, ×100×). (N) The negative expression of NF-κB in colorectal cancer tissues (magnification, ×100). (O) The positive expression of NF-κB in adenoma (magnification, ×100). (P) The positive expression of NF-κB in adjacent normal tissue, where it appears as clear dark brown particles in the cytoplasm (magnification, ×400). (Q) Positive TNF-α protein expression observed mainly in the cytoplasm (brown particles) in colorectal cancer tissues (magnification ×400). (R) The negative expression of TNF-α in colorectal cancer (magnification, ×100). (S) The positive expression of TNF-α in colorectal adenoma (magnification, ×100). (T) The positive expression of TNF-α in normal tissue (magnification, ×100). TLR, Toll-like receptor; NF, nuclear factor; TNF, tumor necrosis factor.