Table 5.

Impact of dose reduction on normal tissue dose by treatment arm.

	Arm B (36 Gy)	Arm B (21 Gy)	Pediatric (36 Gy)	Pediatric (21Gy)	Arm B (36 vs. 21 Gy)	Pediatric (36 vs. 21 Gy)	Arm B (36 Gy) vs. Ped. (21 Gy)
Heart (mean dose)	20.2	11.78	19.39	11.54	8.42	7.85	8.66
(95% Conf. Int.)	(15.47–24.92)	(7.05–16.51)	(14.66–24.11)	(6.82–16.27)	p = 0.0003	p = 0.0009	p = 0.0002
Lung (V20%)	35.09	21.42	42.75	26	13.67	16.75	9.09
(95% Conf. Int.)	(25.39–44.76)	(11.72–31.11)	(33.06–52.44)	(16.31–35.69)	p = 0.0004	p < 0.0001	p < 0.0001
Breast (mean dose)	7.01	4.09	8.52	5.21	2.92	5.6	1.8
(95% Conf. Int.)	(4.11–9.90)	(1.19–6.98)	(5.62–11.41)	(2.31–8.10)	p = 0.1257 (ns)	p = 0.045	p = 0.6356 (ns)