Table 4.
KIR3DS05, KIR3DL10 epistasis with MHC class I alleles on HVL risk.
| KIR3DS05 | KIR3DL10 | |||||||
|---|---|---|---|---|---|---|---|---|
|
MHC class I |
KIR3DS05 |
Epistasis |
Pa |
MHC class I |
KIR3DL10 |
Epistasis |
Pa | |
| MHC class I | ORMHC (p value) | ORKIR (p value) | ORMHCxKIR (p value) | ORMHC (p value) | ORKIR (p value) | ORMHCxKIR (p value) | ||
| A1*001 | 1.50 (p = 0.622) | 21.60 (p = 0.009) | 0.035 (p = 0.020) | 0.041 | 1.40 (p = 0.654) | 21.60 (p = 0.009) | 0.036 (p = 0.024) | 0.041 |
| A1*004 | 11.00 (p = 0.015) | 7.33 (p = 0.034) | 0.20 (p = 0.224) | 3.64 (p = 0.101) | 3.25 (p = 0.167) | 1.10 (p = 0.942) | ||
| B*012 | 0.50 (p = 0.471) | 1.25 (p = 0.755) | 10.00 (p = 0.087) | 0.40 (p = 0.320) | 1.20 (p = 0.811) | 25.00 (p = 0.036) | ||
| B*046 | 2.67 (p = 0.283) | 4.40 (p = 0.044) | 0.26 (p = 0.272) | 1.30 (p = 0.745) | 3.66 (p = 0.084) | 1.03 (p = 0.984) | ||
| B*057 | 6.42 (p = 0.040) | 6.60 (p = 0.028) | 0.17 (p = 0.153) | 2.60 (p = 0.221) | 4.33 (p = 0.089) | 0.58 (p = 0.659) | ||
| B*072 | 10.29 (p = 0.047) | 20.01 (p = 0.014) | 0.054 (p = 0.043) | 3.00 (p = 0.179) | 8.00 (p = 0.029) | 0.29 (p = 0.330) | ||
Displayed are all model term estimates (main effects and epistasis: odds ratio’s OR (p values), p ≤ 0.05 in bold) for twelve models of KIR–MHC class I polymorphism pairings. The two correlated KIR risk genes KIR3DS05 and KIR3DL10 were coded for transcript presence at pre-infection. The MHC class I alleles were coded for transcript presence, did not correlate significantly, and were frequent with sufficient strata sizes. The simultaneous risk estimates ORMHC, ORKIR, and ORMHCxKIR quantify HVL risk of MHC-I in KIR-negative animals (ORMHC), HVL risk of KIR in MHC-I-negative animals (ORKIR) and epistatic effects for coincident presence of KIR and MHC-I (ORMHCxKIR). Animals with coincident MHC-I and KIR presence have the HVL risk ORMHC⋅ORKIR⋅ORMHCxKIR compared to animals with coincident MHC-I and KIR absence.
aProbability that – under the null-hypothesis of no epistasis and no genetic associations – two or more p ≤ 0.05 for six epistasis tests of MHC class I alleles with a KIR gene. This probability was estimated based on 10,000 permutations of the HVL/LVL group assignment.