Fig. 2.
(A) Sequence alignment of segment S6 of NavAb to other Nav channels (showing only FS6-containing domain IV; see SI Appendix, Fig. S1, for full comparison). F201, F203, F207, and N211 in NavAb and F1764 in Nav1.2 are indicated. Amino acids were colored with Jalview (46, 47) using the Zappo scheme. (B) Aligned structures (showing three subunits) of NavAb and model Nav1.2 (based on NavAb) comparing NavAb F201, F203, and F207 to Nav1.2 F1764. Conserved N211 (NavAb numbering) is also indicated.