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Model for dynamic RBP regulation of polysome specificity in neocortical development. HuR differentially binds distinct mRNA subsets in early vs. late neocortical neurogenesis, influencing their active polysomal translation in a temporally dependent manner. The HuR–eIF2ak4 interaction depends on the eIF2ak4 kinase domain and determines the combinatorial composition of polysomal proteins required for the temporally dependent translation of transcripts that specify neocortical circuits.
