Fig. 3.

T2D case/control status in multiethnic individuals harboring nonsynonymous PPARG variants, according to PPARG function in vitro. Each point represents an individual variant; point size denotes the number of individuals carrying that variant. Function in vitro was determined by the ability of each variant to rescue adipocyte differentiation in comparison with WT PPARG. The blue dashed line indicates the threshold for a one-tailed t test below which variants are classified as LOF compared with WT PPARG (P < 0.05). Odds ratios and P values for T2D case status among individuals carrying benign and LOF variants were calculated as described in Methods. *Variants observed only in a single case or control individual.