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Effects of GHSR1a gene deletion on steatosis. GHSR1a−/− mice and wild-type littermates were fed NCD or 45% HFD for 16 wk. Gross morphology of body (A) and liver (B), oil red staining (C), liver and plasma triglyceride content (D), and levels of PPARγ and SREBP1 (E) were shown. Expression of dgat1 and dgat2 (F) was analyzed by real-time RT-PCR, with gapdh as control. n = 6. *P < 0.05 vs. NCD control; #P < 0.05 vs. HFD control.
