Table 3.

Body weight, food intake, blood glucose, and insulin in LepR^−/−,GcgR^−/− mice

Genotype	Body weight, g	Food intake, kcal/d	Blood glucose, mg/100mL	Plasma insulin, ng/mL
LepR−/−,GcgR+/+	59.0 ± 4.3*	22.4 ± 1.1**	455 ± 19.2**,†	38.1 ± 1.3**
LepR−/−,GcgR−/−	45.0 ± 1.6*	15.5 ± 1.1**,‡	70 ± 5.0**,‡	7.2 ± 1.5**,‡
LepR−/−,GcgR−/− + Adv-GcgR	48.0 ± 0.8	24.0 ± 1.7‡	391 ± 33.0‡,†	31.0 ± 3.0‡

n = 6 for each diet/treatment. Body weight, food intake, blood glucose, and plasma insulin are significantly different (P < 0.05) comparing LepR^−/−,GcgR^−/− and LepR^−/−,GcgR^−/− mice. All four parameters are not significantly different comparing LepR^−/−,GcgR^+/+ mice to LepR^−/−,GcgR^−/− treated with Adv-GcgR. Within a column, symbols indicate pairwise comparisons with P < 0.05.