TABLE 1.

Percentage Displacement of 3H-CUMI-101 by (1)-8-OH-DPAT (Selective for 5-HT1A Receptors) and Prazosin (Selective for α₁ Adrenoceptors)

	Percentage displacement of 3H-CUMI-101
	(1)-8-OH-DPAT (50 nM)						Prazosin (50 nM)
	Rat		Monkey		Human		Rat		Monkey		Human
Brain region	37°C	23°C	37°C	23°C	37°C	23°C	37°C	23°C	37°C	23°C	37°C	23°C
Cortex	47 ± 6	43 ± 4	91 ± 3	70 ± 4	87 ± 3	78 ± 2	42 ± 3	45 ± 2	12 ± 2	21 ± 1	10 ± 1	19 ± 2
Thalamus	49 ± 2	39 ± 3	52 ± 3	28 ± 2	66 ± 2	46 ± 3	45 ± 2	51 ± 5	50 ± 4	78 ± 2	43 ± 1	56 ± 3
Cerebellum	16 ± 2	11 ± 3	33 ± 3	NA	NA	25 ± 4	88 ± 4	91 ± 5	25 ± 3	79 ± 6	NA	89 ± 5

NA = 3 null entries for which we had no data.

Data are percentage displacement ± SEM.